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Important Safety Information
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SUPPORT EVERY STEP OF THE WAY

Explore the multiple resources available to help you stay informed and feel supported every step of the way.

NAVIGATING TOGETHER

Getting Started Is Easy

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Once you or your child are prescribed LIVMARLI, Mirum Access Plus experts will help you navigate your insurance coverage and share financial support options that may help lower out-of-pocket costs.

~94%
of patients are
APPROVED
by their insurance for LIVMARLI*
98%
of patients pay
as little as
$10
per fill†

Mirum Access Plus Savings Program

If you have commercial insurance and your insurance coverage for LIVMARLI is approved, Mirum Access Plus can offer:

Eligible patients may pay as little as $10 out of pocket per fill for LIVMARLI‡

Mirum Patient Assistance Program (PAP)

If you are uninsured or coverage is denied, the Mirum Access Plus team will determine your eligibility for the Mirum PAP. Mirum PAP allows you to:

Receive LIVMARLI at no cost to you for up to 1 calendar year, with eligibility reviewed each year†

*Data from 1/1/2022 to 12/31/2023.

†Exceptions apply for some patients, including those with TRICARE insurance.

‡Subject to program terms and conditions.

Mirum Access Plus Resources

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Mirum Access Plus Downloadable Resources

Mirum Access Plus is here to provide you with the resources and education you need, when you need them. Whether it’s answers to your questions, assistance with insurance coverage, or helping you refill your medication, Mirum Access Plus makes it easy to get what you need.

View Available Resources

Mirum Access Plus Mobile

Designed for busy families on the go, Mirum Access Plus Mobile is a convenient text messaging service that makes communicating with Mirum Access Plus even easier.

Enroll in Mirum Access Plus Mobile

If you have any questions about Mirum Access Plus, contact us at:
1-855-MRM-4YOU (1-855-676-4968) Monday through Friday, 8:00 AM through 8:00 PM ET.

LIVMARLI Peer Program

Whether you or your child are taking LIVMARLI, or you’re interested in starting after discussing with your doctor, we’re happy to talk to you! Chat with LIVMARLI peers—parents and caregivers featured in the Videos section who know what it’s like to navigate life with Alagille syndrome. You can count on us to connect you with helpful resources and answer your questions. Whenever you’re ready, we’re here to help.

READY TO CONNECT?

Learn about the LIVMARLI Peer Program and speak one-on-one with a caring peer.

Register for a Phone Call
LEAVE NO QUESTION UNASKED

Talking to Your Doctor

Understanding Alagille syndrome and its treatment can be difficult. Speaking with your child’s doctor can help make things easier.

When partnering with your doctor, conversation is key. It’s helpful to be open and honest so you can work as a team towards your treatment goals. Here are a few things to get the conversation started.

Tell your doctor

  • How the itch impacts daily life
  • Treatment history
  • Any previous surgeries or transplants
  • Other conditions you or your child have
  • Medicines you or your child take
  • Specific goals related to health, treatment, and management of Alagille syndrome

Ask your doctor

  • Could LIVMARLI be an option for me or my child?
  • How will I know if LIVMARLI is working?
  • How is LIVMARLI taken?
  • What are the possible side effects? How can they be managed?
  • Can LIVMARLI be taken if someone has other health conditions or takes other medicines?
  • What support is available while taking LIVMARLI?
  • How do we get started?

WANT TO GET STARTED?

Bring the Discussion Guide to your next visit:

Download English Version Descargar la Versión en Español
YOU’RE QUITE RESOURCEFUL

How LIVMARLI May Help

Whether you’re considering—or already preparing for—treatment, this brochure can help you learn more about LIVMARLI and how it works.

Download: English | Español

Long-Term Impact

If you’re currently treating with LIVMARLI or considering starting, this brochure provides useful information about treating cholestatic pruritus and long-term results.

Download the Long-Term Brochure

A Quick Look at LIVMARLI

Some days, you only have time for a fast skim. This guide can help you quickly browse key information about LIVMARLI.

Download the Quick Look Brochure

Talk to Your Doctor About LIVMARLI

Get ready for your next conversation with your doctor. This guide can help you talk about your treatment goals.

Download: English | Español

A Guide for Teens Taking LIVMARLI

Teenagers may feel ready to take more responsibility for their health. This guide can help teens take charge of their treatment.

Download the Teen LIVMARLI Guide

Identify the Itch

Use this guide to help identify the signs of itch at any age.

Download the Pruritus Finder
ADVOCACY GROUPS

Support at Your Fingertips

ALGSA logo

The Alagille Syndrome Alliance (ALGSA)

ALGSA is a non-profit organization with a goal of supporting the Alagille syndrome community by mobilizing resources, facilitating connections, promoting unity, and advocating for a cure to inspire, empower, and enrich the lives of people affected by Alagille syndrome.

Visit the ALGSAarrow
Yellow Alert logo

Yellow Alert is the Children’s Liver Disease Foundation’s awareness campaign promoting the early identification of liver disease in infants and their referral.

Visit Yellow Alertarrow
CLASS logo

CLASS is an all-volunteer group helping children affected with liver diseases by addressing the emotional, educational, and financial needs of families.

Visit CLASSarrow
NORD logo

The National Organization for Rare Disorders (NORD) is a patient advocacy organization dedicated to individuals with rare diseases and the organizations that serve them. NORD is committed to the identification, treatment, and cure of rare disorders through programs of education, advocacy, research, and patient services.

Visit NORDarrow

Check it. 
Chart it. 
Discuss It.™

Introducing the Itch✓ app: An easy-to-use journal designed to help you and your doctor keep track of your itch.

Download on the Apple App Store Get it on Google Play

Want a Printable Version?

Get an Itch✓ printable journal that you can fill 
out to share with your doctor.

English
Español

Apple®, iPhone®, App Store®, and the Apple Logo are registered trademarks of Apple Inc.

Google Play and the Google Play logo are trademarks of Google LLC.

Indication

LIVMARLI is a prescription medicine used to treat cholestatic pruritus (itch) in patients who are 3 months of age and older with Alagille syndrome.

It is not known if LIVMARLI is safe and effective in children with Alagille syndrome who are under 3 months of age. It is not known if LIVMARLI is safe and effective in adults who are 65 years of age and older.

Important Safety Information

What are the possible side effects 
of LIVMARLI?

  • Liver injury. Changes in certain liver tests are common in patients but may worsen during treatment with LIVMARLI. These changes may be a sign of liver injury and can be serious. Your health care provider should do blood tests and physical exams before starting and during treatment to check your liver function. Tell your health care provider right away if you get any signs or symptoms of liver problems, including:
    • nausea or vomiting
    • your skin or the white part of your eye turns yellow
    • dark or brown urine
    • pain on the right side of your stomach (abdomen)
    • fullness, bloating, or fluid in your stomach area (ascites)
    • loss of appetite
    • bleeding or bruising more easily than normal, including vomiting blood
  • Stomach and intestinal (gastrointestinal) problems. LIVMARLI can cause stomach and intestinal problems, including diarrhea and stomach pain during treatment. Diarrhea can also cause the loss of too much body fluid (severe dehydration). Your health care provider may advise you to monitor for new or worsening stomach problems, including stomach pain, diarrhea, blood in your stool, or vomiting. Tell your health care provider right away if you have any new or worsening signs or symptoms of stomach and intestinal problems, including:
    • diarrhea
    • more frequent bowel movements than usual
    • stools that are black, tarry, or sticky, or have blood or mucous
    • severe stomach-area pain or tenderness
    • vomiting
    • urinating less often than usual
    • dizziness
    • headache
  • A condition called Fat-Soluble Vitamin (FSV) Deficiency caused by low levels of certain vitamins (vitamin A, D, E, and K) stored in body fat. FSV deficiency is common in patients with Alagille syndrome but may worsen during treatment. Your health care provider should do blood tests before starting and during treatment, and may monitor for bone fractures and bleeding, which are common side effects.

Tell your health care provider about all medicines that you take, as LIVMARLI may interact with other medicines. If you take a medicine that lowers cholesterol by binding bile acids, such as cholestyramine, colesevelam, or colestipol, take it at least 4 hours before or 4 hours after you take LIVMARLI.
Your health care provider may change your dose, or temporarily or permanently stop treatment if you have certain side effects.

LIVMARLI is taken by mouth, 1 time each day, 30 minutes before a meal in the morning. Be sure to use the provided oral dosing dispenser to accurately measure the dose of medicine.

These are not all of the possible side effects of LIVMARLI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Indication

LIVMARLI is a prescription medicine used to treat cholestatic pruritus (itch) in patients who are 3 months of age and older with Alagille syndrome.

It is not known if LIVMARLI is safe and effective in children with Alagille syndrome who are under 3 months of age. It is not known if LIVMARLI is safe and effective in adults who are 65 years of age and older.

Important Safety Information

What are the possible side effects 
of LIVMARLI?

  • Liver injury. Changes in certain liver tests are common in patients but may worsen during treatment with LIVMARLI. These changes may be a sign of liver injury and can be serious. Your health care provider should do blood tests and physical exams before starting and during treatment to check your liver function. Tell your health care provider right away if you get any signs or symptoms of liver problems, including:
    • nausea or vomiting
    • your skin or the white part of your eye turns yellow
    • dark or brown urine
    • pain on the right side of your stomach (abdomen)
    • fullness, bloating, or fluid in your stomach area (ascites)
    • loss of appetite
    • bleeding or bruising more easily than normal, including vomiting blood
  • Stomach and intestinal (gastrointestinal) problems. LIVMARLI can cause stomach and intestinal problems, including diarrhea and stomach pain during treatment. Diarrhea can also cause the loss of too much body fluid (severe dehydration). Your health care provider may advise you to monitor for new or worsening stomach problems, including stomach pain, diarrhea, blood in your stool, or vomiting. Tell your health care provider right away if you have any new or worsening signs or symptoms of stomach and intestinal problems, including:
    • diarrhea
    • more frequent bowel movements than usual
    • stools that are black, tarry, or sticky, or have blood or mucous
    • severe stomach-area pain or tenderness
    • vomiting
    • urinating less often than usual
    • dizziness
    • headache
  • A condition called Fat-Soluble Vitamin (FSV) Deficiency caused by low levels of certain vitamins (vitamin A, D, E, and K) stored in body fat. FSV deficiency is common in patients with Alagille syndrome but may worsen during treatment. Your health care provider should do blood tests before starting and during treatment, and may monitor for bone fractures and bleeding, which are common side effects.

Tell your health care provider about all medicines that you take, as LIVMARLI may interact with other medicines. If you take a medicine that lowers cholesterol by binding bile acids, such as cholestyramine, colesevelam, or colestipol, take it at least 4 hours before or 4 hours after you take LIVMARLI.
Your health care provider may change your dose, or temporarily or permanently stop treatment if you have certain side effects.

LIVMARLI is taken by mouth, 1 time each day, 30 minutes before a meal in the morning. Be sure to use the provided oral dosing dispenser to accurately measure the dose of medicine.

These are not all of the possible side effects of LIVMARLI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.